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Better dynamic range in-camera so as not to have to futz around so much in post processing.

Get rid of the crosshatched banding at ISO 100 and 200 at least.  It's 2010, no modern camera should have this issue and the 5d2 is the only one that does. Makes it almost impossible to push files much more than 1/2 stop in post.

Two stops better ISO noise performance to keep up with competition.

Locking for the mode dial.  I know that they are now offering this as an upgrade on the 5d2 and it should be standard.

Improved shutter lag time, better AF, and a few more megapixels would be nice.