ASUS Prime B350M-E AM4 Micro-ATX Motherboard

ASUS Prime B350M-E AM4 Micro-ATX Motherboard

ASUS Prime B350M-E AM4 Micro-ATX Motherboard

ASUS Prime B350M-E AM4 Micro-ATX Motherboard

ASUS Prime B350M-E AM4 Micro-ATX Motherboard

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Product Highlights

  • Micro-ATX Form Factor
  • AMD B350 Chipset
  • AM4 Socket
  • 2 x Dual-Channel DDR4-3200 (OC)
  • 4 x SATA III, 2 x M.2 Socket 3
  • 1 x PCIe 3.0/2.0 x16 Slot
  • 2 x PCIe 2.0 x1 Slot
  • USB 3.1 | USB 3.0 | USB 2.0 | HDMI | DVI
  • Realtek ALC887 8-Channel HD Audio Codec
  • Realtek RTL8111H Gigabit LAN
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  • 1Description

Maximize connectivity and speed with the Prime B350M-E AM4 Micro-ATX Motherboard from ASUS. It supports NVMe M.2, USB 3.1 Type-A, DDR4 memory, Gigabit LAN, PS/2, and more. This motherboard is compatible with AMD Ryzen, 7th Generation A-Series, and Athlon processors and designed to fit in Micro-ATX (mATX) sized cases, supports the AM4 socket, the AMD B350 chipset, and is compatible with Windows 10 (64-bit).

The mATX form factor of the Prime B350M-E can support 32GB of DDR4 RAM, or 16GB in each of the two slots. Ryzen processors support memory speeds of 3200 (OC), 2933 (OC), 2666, 2400, and 2133 MHz, while 7th Generation and Athlon processors support memory speeds of 2400 and 2133 MHz. It also has a total of 4 x SATA III 6 Gb/s ports that support RAID 0, 1, and 10, plus 1 x M.2 Socket 3 connector that supports Type 2242/2260/2280 storage devices. While Ryzen processors support both PCIe 3.0 x4 and SATA devices, 7th Generation and Athlon processors only support SATA devices.

There are also two USB 3.1 Type-A ports and four USB 3.0 Type-A ports, all at the back panel, as well as one USB 3.0 connector and two USB 2.0 connectors, all of which are internal. For those looking to expand their system using PCIe, there is one PCIe 3.0/2.0 x16 slot and two PCIe 2.0 x1 slots. While Ryzen processors support the PCIe 3.0/2.0 slot at x16, 7th Generation and Athlon processors only support x8.

For delivering sharp, clear graphics, this motherboard supports integrated AMD Radeon R Series Graphics in 7th Generation A-Series APUs with access to up to 2048MB of shared graphics memory and is equipped with HDMI 1.4b, DVI-D, and VGA video outputs. The HDMI output supports a maximum resolution of 4096 x 2160 @ 24 Hz and 2560 x 1600 @ 60 Hz, and the DVI-D and VGA ports support a maximum resolution of 1920 x 1200 @ 60 Hz.

Using the Realtek ALC887 8-Channel HD audio codec, this motherboard can support 8-channel HD audio using its three audio jacks. The motherboard is also equipped with features such as Gigabit Ethernet, DIGI+ VRM, DRAM overcurrent protection, ESD guards, 8000+ validation hours, Fan Xpert, and more. Included is an I/O shield, two SATA III 6 Gb/s cables, and an M.2 screw package. Protection is provided by a limited 3-year warranty.

Stability and Compatibility

5X Protection III
PRIME B350 series motherboards are engineered with 5X Protection III, employing strong components, excellent circuit design, and exacting standards to help guarantee the quality and long-term durability of your motherboard. That means protection and stability for your build.
ASUS SafeSlot
SafeSlot is the PCIe slot reinvented by ASUS and engineered to provide improved retention and shearing resistance. Manufactured in a single step using an insert-molding process to integrate the slot with fortifying metal support for a stronger design, SafeSlot is then firmly anchored to the motherboard through additional solder points.
ASUS LANGuard is hardware-level networking protection that employs signal-coupling technology and anti-EMI surface-mounted capacitors to help ensure a more reliable connection and better throughput, plus electrostatically guarded and surge-protected components for greater tolerance to static electricity and improved protection against surges.
Overvoltage Protection
A circuit design with built-in voltage regulators to help protect your chipset, connectivity ports, and audio codecs from damage caused by unexpected high-level voltages from unstable or inferior power supplies.
DIGI+ VRM - Precision Control for Stable Power
ASUS' DIGI+ VRM intelligently delivers power to the processor based on real-time demands, reducing energy waste and improving system stability.
DRAM Overcurrent Protection
Onboard resettable fuses prevent overcurrent and short-circuit damage. This extends beyond I/O ports to DRAM to safeguard the lifespan of your system and connected devices.
Stainless-Steel Back I/O
Corrosion-resistant stainless-steel back I/O panels bonded with chromium oxide have a lifespan that's longer than ordinary panels.
ESD Guards
ASUS ESD Guards help prevent damage from electrostatic discharge, up to ±10kV for air discharge and ±6kV for contact discharge, arranged in an active-protective-circuit design that helps prolong the life of components. ESD guards help protect the LAN port, USB connects, VGA connectors, and keyboard/mouse connectors


1000+ Compatible Devices and Components
Tested to be compatible with 1000+ CPUs, DDR4 memory modules, graphics cards, sounds cards, optical drives, and more.


8000+ Validation Hours
ASUS motherboards have superb endurance. This is verified by subjecting every board to more than 8000 hours of stringent tests. A barrage of burn-in, environmental, compatibility, software, and safety tests confirm that every motherboard is robust.
Temperature and Humidity Test
Ensures components withstand extreme conditions.
Thermal Measurement Test
Ensures that the system remains cool and stable under the heaviest loads.
Insertion Test
Every port and connector is put through repeated installation cycles.
Aging Test
Up to 48-hour aging test ensures reliability.
Power Consumption Test
Checked for energy efficiency.
Temperature and DC Margin Test
Ensures that the motherboard is capable of coping with voltage fluctuations caused by varying temperatures.
Thermal Shock Test
Helps ensures the ability to survive temperature changes during transportation, ranging from -40 to 185°F / -40 to 85°C.
Non-Operation Shock Test
Built to withstand jolts that may occur during shipping.
Burn-In Test
Every component is checked to ensure operation in most environments.
Installation Test
Connector placement is double-checked to help ensure a user-friendly installation.
Drop Test
Drop tests from various heights help ensure durability.
Salt and Spray Test
Tested for I/O reliability, prolonged lifespan, and rust-resistance.


DDR4 Support
With DDR4, you'll accelerate memory frequencies up to 3200 MHz. ASUS works with almost every DDR4 memory vendor, so you're assured a wide range of compatibility.

Optimized Cooling

Fan Xpert
Fan Xpert helps ensure every fan achieves a good balance of cooling performance and low noise. With Prime B350M-E series boards and their hardware-level 4-pin/3-pin PWM/DC mode for case fans, a simple BIOS adjustment lets you run your case fan in PWM/DC. Fan Xpert even includes Auto-Tuning mode to scan and detect all fan characteristics for single-click customization.

Game in Your Way

Gaming Audio
Noise Isolation
Audio shielding ensures precision analog/digital separation and reduced multi-lateral interference.

Dedicated Audio PCB Layers
Separate layers for left and right tracks help ensure both channels deliver consistent and equal quality.

Audio Enjoyment
Japanese audio capacitors provide warm, natural, and immersive sound with strong clarity and fidelity.

Energy Saving

Energy Efficient Design
With the Energy Processing Unit (EPU), you'll enjoy system power savings. The EPU automatically optimizes power consumption and maximizes savings with Away mode.

Fast Transfer Speeds

10 Gb/s USB 3.1 Onboard
With backward-compatible USB 3.1 Type-A, you'll experience connection flexibility and data transfer speeds of up to 10 Gb/s.
Speed Up with Onboard M.2 up to 32 Gb/s
With PCI Express 3.0/2.0 x4 bandwidth, M.2 supports data transfer speeds of up to 32 Gb/s. It is a good choice for an operating system or application drive, making your whole PC or professional apps work faster.


The large winged clip is easy to reach and easy to operate. Just press the Q-Slot clip lightly, and the graphics card pops out. Installing or removing even the biggest graphics cards is user-friendly.
Even if you work with a smaller case, just push down on the one-sided clip and push or pull RAM modules in or out.

One-Stop Controls

The mouse-controlled graphical BIOS has been improved to make it even more appealing. Whether you're a PC novice or a seasoned overclocker, EZ and Advanced modes help you find your way, quickly and easily.

EZ Flash 3
Update the BIOS via the Internet, without leaving the BIOS interface.

Check your storage device Self-Monitoring, Analysis, and Reporting Technology logs to gauge reliability and possibly to determine potential failures.

Q-Fan Control
You can configure the fan's operating speed manually, or use the easy pre-configured fan profiles to select Standard, Silent, Turbo, or Full Speed modes.

My Favorite
Quickly find tuning options and add preferred tools to the list.
EZ Mode
Intuitive Graphical Fan Control
Fine-tune individual fans simply by dragging a curve with the mouse.

Improve DRAM performance with a click.

SATA Information
Display SATA port details for device identification.

Fast Clock Adjustment
Use mouse controls to quickly change time and date settings.
Advanced Mode
Last Modified Log
Track last change and save preferred profiles onto a USB drive.

SATA Port Renaming
Rename SATA ports for easy identification.
AI Suite 3
ASUS AI Suite 3 offers a user experience through a clearer and more attractive interface with support for larger monitors. It consolidates all ASUS features into one simple-to-use package, allowing you to supervise overclocking, energy consumption, fan speeds, voltages, and more. This all-in-one app offers easy-to-use functionality, with no need to switch back and forth between different utilities.

AMD CPU and Chipset Features

Ready for AMD AM4-socket Ryzen, 7th Generation A-series APUs, and Athlon APUs
This motherboard supports AMD Ryzen processors, 7th Generation A-series accelerated processing units (APUs), and Athlon CPUs. The Ryzen processor supports up to eight cores and is based on Zen core architecture. The 7th Generation A-series APUs feature integrated AMD Radeon R-series graphics. AMD AM4-socket processors feature dual-channel DDR4 memory, native 5 Gb/s USB 3.0, and 16 PCI Express 3.0/2.0 lanes.
AMD B350 Chipset
The AMD B350 chipset delivers overclocking capabilities for AMD AM4-socket Ryzen processors, 7th Generation A-Series APUs, and Athlon CPUs. It provides two 10 Gb/s USB 3.1 ports, two USB 3.0 ports, and four SATA III ports for faster data retrieval.
UPC: 889349672082
In the Box
ASUS Prime B350M-E AM4 Micro-ATX Motherboard
  • I/O Shield
  • 2 x SATA III 6 Gb/s Cables
  • 1 x M.2 Screw Package
  • Limited 3-Year Warranty
  • Table of Contents
    • 1Description
    Chipset AMD B350
    CPU Socket AM4
    Back Panel I/O
    USB 2 x USB 3.1 Type-A
    4 x USB 3.0 Type-A
    Display 1 x HDMI 
    1 x DVI-D 
    1 x VGA 
    Audio 3 x 3.5 mm
    Ethernet / Controller  
    PS/2 2 x PS/2
    Legacy Not Specified by Manufacturer
    Wi-Fi Antenna Not Specified by Manufacturer
    Buttons Not Specified by Manufacturer
    Memory Slots 2 x 288-Pin
    Memory Support DDR4 2133, 2400, 2666, 2933, 3200 MHz
    Maximum Capacity 32 GB
    Channel Architecture Dual Channel
    ECC Support Non-ECC, ECC Unbuffered
    Storage Expansion
    M.2 1 x M Key 2242, 2260, 2280, 22110 (PCIe 3.0 x4, SATA III)
    U.2 None
    RAID Support RAID 0, 1, 10
    Internal I/O
    Expansion Slots 1 x PCIe 3.0 x16
    2 x PCIe 2.0 x1
    USB 1 x USB 3.0 Header (Supports 2 USB Type-A Ports)
    2 x USB 2.0 Header (Supports 4 USB Type-A Ports)
    Multi-GPU Support None
    Air Cooling 1 x 4-Pin CPU
    1 x 4-Pin System
    Liquid Cooling Not Specified by Manufacturer
    Power Connectors 1 x 24-Pin Mainboard
    1 x 4-Pin CPU
    Security Not Specified by Manufacturer
    LED Header None
    Audio 1 x S/PDIF
    1 x Speaker
    Diagnostics Clear CMOS
    Add-On Not Specified by Manufacturer
    Legacy 1 x Serial
    ROM 128 Mb
    Front Panel I/O
    I/O Connection Headers AAFP
    Audio Codec Realtek ALC887 (8-Channel)
    Bluetooth Version Not Specified by Manufacturer
    Wi-Fi None
    Module Support Not Specified by Manufacturer
    Supported Operating Systems Windows 10 (64-Bit)
    Form Factor Micro-ATX
    Dimensions 8.9 x 8.7" / 22.6 x 22.1 cm
    Packaging Info
    Package Weight 1.95 lb
    Box Dimensions (LxWxH) 10.7 x 10.4 x 2.2"
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