The VEO 42 Backpack from Vanguard has a removable and customizable padded insert that can hold a DSLR with up to an 80-300mm lens, and an easy-access sleeve for a laptop or tablet up to 13". Zippered front pockets hold accessories like memory cards and batteries, and adjustable side pockets can hold tripods, monopods, or other similarly sized gear.
On the back of the bag is a trolley slot so that you can slide the bag over the handle on rolling luggage. The adjustable hardness straps work together with chest straps to take weight off of your shoulders. A rain cover is included to protect the bag in inclement weather.