No. It's the same signal on both ports.

Basically, we are seeing information that suggests it works. However, we cannot confirm since it depends on your computer and making sure you have the proper drivers. We suggest contacting Blackmagic Design for further information.

The Blackmagic Design DeckLink Mini Monitor 4K offers simultaneous HDMI and SDI output.

The display will work with the card. Check the list of supported formats to make sure the format of interest is supported by the card.

The Blackmagic Design DeckLink Mini Monitor 4K can output at two different resolutions, so long as the software you are using to send the signals supports such a set up.

How much acceleration would you expect from a 10 watt card? It is only for monitoring. The key purpose that it provides is a full screen video output for monitoring to your grading monitor - so you need two monitors, one connected via HDMI or SDI to this card, and the other with your tools, files, timeline etc on the other monitor. It's the other graphics card that does any GPU acceleration that you may be doing. I see the key reason to use this card being if you want to monitor/grade HDR content, this seems to be the only way to do it, and why I use the card. Note however, while the HDR luminance is correctly sent using the EOTF-2084 protocol, the card and software fails to set the metadata to automatically set the color space of the content. So you need a monitor where you can via the OSD set the color space yourself. I use the Asus PG27UQ and PA32UCX both allow you to set the color space via the OSD, although doing so for the PG27UQ needs to be first set in SDR mode, but it carries over the setting to the HDR mode.

You didn't say, but are you doing HDR or SDR? Also what frame rate are you editing at, the Mini Monitor 4K won't drive 4K/60/10bit so if you're doing 10bit it will run at 4K/30 which is fine, and your project can still be 4K/60. What is your purpose/expectation of the preview, are you doing this for sharpness/focus in which case you really do need 4K, otherwise 1080P might be an option if you're only using it for color preview that might make it cheaper and would also enable 1080P/60/10bit. If you're doing it for color, then getting a display that accurately displays the color gamut is the most important aspect. For this you can either get a display that is factory calibrated to a tight tolerance or do the calibration yourself, something like Calman can be used, but unless you have this already it might be a problem for a tight budget. So if it's just color grading and you want 4K for SDR editing, a monitor that claims 99-100% of sRGB and a tight Delta-E (3 would be passable, 2 good, 1 great) then you're probably set. If you're editing in HDR this opens many other challenges up, including the sustained MaxLuminance and EOTF accuracy of the display. You can use TV's but the ones I've measured (from all the major brands) have "interesting" EOTF-2084 tracking of luminance and thus aren't particularly useful for color grading. It's not cheap, but the Asus PG27UQ is a great monitor with excellent EOTF-2084 tracking and a small Delta-E due to the factory calibration - that's what I use with the DeckLink Mini Monitor 4K for 4K/HDR grading.

Yes, The Blackmagic Design DeckLink Mini Monitor 4K could work with this Thunderbolt 3 chassis https://bhpho.to/36I4VC8 and if you have a Thunderbolt 2 Mac you could use this bi-directional adapter to connect to your TB2 Mac https://bhpho.to/36KTc5N